The Liver-Lung Vascular Connection

Osteoprotegerin: osteo-vascular connection.

Regulation of vascular tone: the fat connection.

The study of vascular tone regulation has been based traditionally on layer-specific mechanisms. Three different layers form the blood vessel wall: intima, media, and adventitia. The intima is a monolayer of endothelial cells, which separates circulating blood from the medial layer underneath. The media consists of concentric layers of smooth muscle cells and elastic lamella, varying in number ...

Hepatopulmonary syndrome--a liver-induced lung vascular disorder.

From Servei de Pneumologia (Institut del Tòrax), Hospital Clínic, Institut d’Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Ciber Enfermedades Respiratorias, and the University of Barcelona — all in Barcelona; and the Pulmonary and Critical Care Division, Mayo Clinic, Rochester, MN. Address reprint requests to Dr. Rodríguez-Roisin at Servei de Pneumologia, Hospital Clínic, Villarroel,...

The Role of Anion Exchanger on Pulmonary Vascular Response to Sustained Alveolar Hypoxia in the Isolated Perfused Rabbit Lung

Background: Some respiratory diseases may induce alveolar hypoxia thereby hypoxic pulmonary vasoconstriction (HPV). However, the mechanisms of this physiologic phenomenon are not fully understood. This study was the first to investigate the role of anion exchanger in sustained HPV.Methods: Experiments were performed in the isolated perfused rabbit lung. After preparation, the lungs were divided...

Vascular remodelling in the lung.

In the 1960s, studies on lungs of normal, high altitude dwelling natives demonstrated distinct structural differences in the pulmonary vasculature, compared to native sea level dwellers, accompanied by mild pulmonary hypertension [1]. ARIAS-STELLA and SALDANA [2] reported an increase in medial muscle mass in the distal segments of the pulmonary arterial tree. This was considered not to be due t...